FIELD: medicine.
SUBSTANCE: vaccine strain of A/17/Brisbane/07/28 (H1N1) influenza virus is a reassortant prepared by cross breeding an epidemic A/ Brisbane /59/07 (H1N1) virus and a cold-adapted thermally sensitive A/Leningrad/134/17/57 (H2N2) virus being a human-safe attenuation donor. The A/17/Brisbane/07/28 (H1N1) strain replicates actively in growing chicken embryos at optimum temperature 32°C. The reassortant has inherited the genes coding surface virus antigens - hemagglutinin (HA) and neuraminidase (NA) from an epidemic parent virus, and six genes coding internal non-glycosylated proteins from the attenuation donor. The A/17/Brisbane/07/28 (H1N1) strain is areactogenic for adults and children in intranasal introduction. In reactogenecity, the vaccine strain of A/17/Brisbane/07/28 (H1N1) influenza virus meets the requirements specified in the Manufacturer's Monograph 42-0417-4097-03 to vaccine strains for live dry allantoic influenza vaccine for intranasal application.
EFFECT: strain is characterised by thermal sensitivity and cold adaptation.
1 dwg, 3 tbl
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