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2 413 765

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IPC

C12N7/00(2006-01-01)

A61K39/145(2006-01-01)

(21) (22)

Application

2009134769/10, 2009-09-16

(24)

Start date

2009-09-16

(22)

Actual filing date

2009-09-16

(45)

Published

2011-03-10

(72)

Inventor

Larionova Natal'Ja ValentinovnaKiseleva Irina Vasil'EvnaRudenko Larisa GeorgievnaAleksandrova Galina Ibragimovna

(73)

Holder

Uchrezhdenie Rossijskoj Akademii Meditsinskikh Nauk Nauchno-Issledovatel'Skij Institut Ehksperimental'Noj Meditsiny Severo-Zapadnogo Otdelenija Ramn Szo Ramn)

VACCINE STRAIN OF FLU VIRUS A/17/CALIFORNIA/2009/38 (H1N1) FOR PROFUCTION OF LIVE INFLUENZA INTRANASAL VACCINE FOR ADULTS AND CHILDREN Russian patent published in 2011 - IPC C12N7/00 A61K39/145

Abstract RU 2413765 C1

FIELD: medicine.

SUBSTANCE: vaccine strain A/17/California/2009/38 (H1N1) - reassortant, obtained by crossing new pandemic virus A/17/California/2009 (H1N1) with cold-adapted temperature-sensitive virus A/Leningrad/134/17/57 (H2N2) -donor of attenuation, harmless for people. Strain A/17/California/2009/38 (H1N1) actively multiplies in developing chicken embryos at optimal temperature 32-33°C, is characterised by temperature sensitivity and cold adaptation. Reassortant inherited genes, coding superficial antigens of virus hemagglutinine (HG) and neuraminidase (NA), from potentially pandemic virus and the remaining six genes, coding internal unglycolised proteins from donor of attenuation.

EFFECT: invention can be used in practical health care for prevention of cases of pandemic influenza among adults and children by means of live influenza intranasal vaccine from influenza virus strain.

1 dwg, 7 tbl

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RU 2 413 765 C1

Authors

Larionova Natal'Ja Valentinovna

Kiseleva Irina Vasil'Evna

Rudenko Larisa Georgievna

Aleksandrova Galina Ibragimovna

Dates

2011-03-10—Published

2009-09-16—Filed