MANICHINO-09 STRAIN OF RABBIT HEMORRHAGIC DISEASE VIRUS FOR PREPARING VACCINES AND DIAGNOSTIC PRODUCTS Russian patent published in 2011 - IPC C12N7/00 A61K39/12 

FIELD: medicine.

SUBSTANCE: shown is antigen and immunogenic efficacy of a new Manichino-09 strain used for preparing an inactivated RHDV vaccine. The vaccine contains an antigen material of the Manichino-09 strain of rabbit hemorrhagic disease virus, formalin, sodium metabisulphite, aluminium hydroxide gel in the effective proportions. The strain is deposited in the collection of VGNKI, registration name Manichino-09 - DEP rabbit hemorrhagic disease virus. The virus is reproduced in vivo in a European rabbit (Oryctolagus cuniculus) of 1.5 month and older, free from the disease antibodies or having a RHDV antibody titre lower than 1:4. An inactivant is 4% formalin (i.e. 1.1-1.4% formaldehyde). The sorbed vaccine is prepared of adjuvants with using aluminium hydroxide gel (AHG).

EFFECT: vaccine exhibits high antigen and immunogenic activity.

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