METHOD FOR INDIVIDUAL DOSAGE OF RADIOIODINE-131 IN TREATING PATIENTS WITH TOXIC GOITER Russian patent published in 2011 - IPC A61B5/00 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, specifically to endocrinology, radiology, therapy. It involves physical examination of a patient. A percentage of iodine-131 test dose capture in 4 hours, a percent of iodine-131 test dose capture in 24 hours, ultrasound thyroid size, blood free thyroxine (pmol/l), duration of the disease, sex of the patient, duration of thyrostatic withdrawal before a therapeutic dose of radioiodine-131, age of the patient at a first manifestation of said disease, presence of thyroid resection in anamnesis, mercasolyl (thyrozol) dose just before drug withdrawal. Further, upper and lower limits of recommended individual radioiodine (I) dosage range for the certain patient. The lower dosage limit is derived from solving a problem of predicting a dose for negative therapeutic effect events, and the upper limit - for positive effect events. The reliability of positive or negative therapeutic effect is estimated by the prescribed dosage on the basis of solving the classification problem wherein a clinical data base of the prescribed doses supplements input data composition. The therapeutic effect is considered to be an output parametre, while the reliability estimation is represented in the form of a number range 0 to 1; a zero value of the range is interpreted as the negative effect, while the unit value shows the positive effect. The calculated range of the recommended doses is specified by examining the doses in vicinities of the borders with a preset dose look providing therapy confidence as 0.5 for the left border and 0.9 for the right border. The recommended dose is that one that corresponds to the right border of the specified range of the recommended doses.

EFFECT: method provides higher accuracy of individual dosage ensured by considering a great amount of patient's parametres having an action on the therapeutic effect.

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