FIELD: medicine; endocrinology.
SUBSTANCE: invention can be used to predict the effectiveness of radioiodine therapy in the treatment of Graves' disease. Perform blood sampling and testing. The percentage of B-lymphocytes — CD19+ and activated T-helpers — CD3+CD4+CD25+CD45+ is determined in patients before radioiodine therapy (RIT) using the flow cytometry method. Then the value of the T-helper regulation coefficient (THR) is calculated, which is the ratio of the percentage of activated T-helpers to the percentage of B-lymphocytes. If the TCR value is below 0.105, the development of persistent post-radiation hypothyroidism is predicted within 6 months after RIT. If the TCR value is equal to or exceeds 0.105, the absence of a persistent decrease in thyroid function — hypothyroidism is predicted in the outcome of radionuclide treatment within 6 months after RIT.
EFFECT: informative early prediction of the effectiveness of RIT in Graves' disease by determining the percentage of B-lymphocytes and activated T-helpers in patients before RIT using flow cytometry.
1 cl, 4 ex
Title | Year | Author | Number |
---|---|---|---|
METHOD FOR PERSONALIZED APPROACH TO CHOOSING METHOD FOR TREATMENT OF GRAVES DISEASE | 2022 |
|
RU2794815C1 |
METHOD FOR PREDICTING THE DEVELOPMENT OF RELAPSE IN THE MEDICAL TREATMENT OF GRAVES' DISEASE | 2021 |
|
RU2778614C1 |
METHOD FOR PREDICTION OF CLINICAL COURSE OF ENDOCRINE OPHTHALMOPATHY IN PATIENTS WITH GRAVES DISEASE BY DETECTING ANTI-THYROID PEROXIDASE ANTIBODIES | 2011 |
|
RU2460072C1 |
METHOD OF DETERMINING VOLUME OF FUNCTIONAL TISSUE OF THYROID GLAND | 2009 |
|
RU2408269C2 |
METHOD FOR DETERMINING INDIVIDUAL ACTIVITY OF 131-IODINE FOR RADIOIODINE THERAPY OF THYROTOXICOSIS AND PREDICTION OF TIME FOR ACHIEVING A SAFE LEVEL OF 131-IODINE ACTIVITY IN THE PATIENT'S BODY AFTER ADMINISTERING INDIVIDUAL 131-IODINE ACTIVITY | 2019 |
|
RU2722568C1 |
DIFFERENTIAL DIAGNOSTIC TECHNIQUE FOR TYPE 1 AND 2 CORDARON-INDUCED THYROTOXICOSIS | 2011 |
|
RU2478969C1 |
METHOD OF TREATING HASHIMOTO DISEASE | 2009 |
|
RU2410089C1 |
METHOD FOR PREVENTING THYROID GLAND FUNCTION DISORDERS IN NEWBORN CHILDREN | 2001 |
|
RU2199983C2 |
METHOD OF TREATING HYPOTHYROIDISM | 2009 |
|
RU2407533C1 |
METHOD OF PREDICTING PROTRACTED COURSE OF ADAPTATION DISORDER IN WOMEN WITH HYPOTHYROIDISM | 2023 |
|
RU2813697C1 |
Authors
Dates
2023-03-07—Published
2022-04-15—Filed