OXOQUINAZOLINYL-BUTANAMIDE DERIVATIVES Russian patent published in 2018 - IPC C07D401/14 C07D401/06 C07D413/14 C07D417/14 A61K31/517 A61K31/5377 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a novel compound of formula I and a pharmaceutically acceptable salt thereof. In formula I Z is X is CH or N, R¹ is H, R² is H or F, R³ is H, CH₃ or F, R⁴ is H, CN, OCH₃, 1-ethyl-1H-pyrazol-4-yl, 1-(2-methoxyethyl)-1H-pyrazol-4-yl or 1-(2-pyrrolidin-1-ylethyl)-1H-pyrazol-4-yl, R⁵ is H, CH₃, F or OCH₃, R⁶ is CN or 2-pyrimidinyl, R⁷ is Het², Het² is pyrazolyl or imidazolyl, each of which can be substituted with A, A is a straight or branched alkyl containing from 1 to 6 C atoms, where from 1 to 3 H atoms can be replaced by F and/or OH. Invention also relates to a process for the preparation of compounds of formula I by reacting a compound of formula II with a compound of formula III where Z, R¹, R² and R³ are as defined in claim 1 and L is Cl, Br, I or a free or reactive functionally modified OH group.

EFFECT: compounds possess the properties of a tankyrase inhibitor (TANK) and/or poly (ADP-ribose) polymerase (PARP) and can be used for the treatment of diseases such as malignant neoplasm, multiple sclerosis, cardiovascular diseases, CNS lesions and various forms of inflammation.

4 cl, 2 tbl, 12 ex