FIELD: medicine, pharmaceutics.
SUBSTANCE: tablet contains from 3 to 50 wt % (weight/weight), per whole tablet of (S)-N-[2-(1,6,7,8-tetrahydro -2H-indeno[5,4-b]furan-8-yl)ethyl] propione amide (RAMELTEON), magnesium stearate and hydroxylpropyl cellulose, which has viscosity from approximately 1 to approximately 4 mPa·s.
EFFECT: tablet in accordance with the invention ensures reduction of fluctuations in mode of dissolution of sparingly soluble active ingredient ramelteon achieving ratio of similitude f2 of dissolution process in the interval from 50 to 100.
2 dwg, 4 tbl, 1 ex
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