HETEROCYCLIC COMPOUND Russian patent published in 2023 - IPC C07D498/04 A61K31/5365 A61P1/10 

FIELD: chemistry.

SUBSTANCE: present invention relates to a compound represented by Formula (I), in which X represents O, Y represents CR⁵, R¹ and R² each represent a hydrogen atom, R³ represents a hydrogen atom, R⁴ represents C_{1- 6} alkyl group substituted with methoxy, R⁵ represents a fluorine atom, ring A represents: , or its salts. Also the following is proposed: an individual compound - 2-fluoro-4-((3-((3R,4S)-3-hydroxytetrahydro-2H-pyran-4-yl)-4-oxo-3,4,8,9-tetrahydro-2H-benzofuro[5,4-e][1,3]oxazin-6-yl)methyl)-N-(2-methoxyethyl)benzamide or its salt, drug, method for positive allosteric modulation of the cholinergic muscarinic receptor M1, method for prevention or treating constipation in a mammal and using these compounds in the preparation of a prophylactic or therapeutic agent for constipation.

(I)

EFFECT: present compounds have positive allosteric modulator activity of the cholinergic M1 muscarinic receptor and may be useful for the prevention or treatment of constipation and equal.

9 cl, 6 tbl, 11 ex