ACID PUMP ANTAGONIST FOR TREATING DISEASES ASSOCIATED WITH PATHOLOGICAL IMPAIRMENT OF GASTROINTESTINAL MOTILITY Russian patent published in 2016 - IPC A61K31/4188 A61K31/4184 A61K31/437 A61K31/506 A61P1/04 A61P1/00 A61J1/00 

FIELD: chemistry.

SUBSTANCE: invention relates to use of compound possessing activity of acid pump antagonizer, for preparing of drug for improving gastrointestinal motility in diseases associated with pathological gastrointestinal motility, for inducing III phase of migrating inter-digestive contractions (IMC). Said compound can be selected from group comprising: (S)-(-)-4-[(5,7-difluor-3,4-dihydro-2H-chromen-4-yl)oxy]-N,N,2-trimethyl-1H-benzimidazole-6-carboxamide;(-)-1-(2-methoxyethyl)-N,N,2-trimethyl-8-phenyl-1,6,7,8-tetragidrohromeno[7,8-d]imidazole-5-carboxamide; 1-[5-(2-fluorophenyl)-1-(pyridin-3-ilsul′fonil)-1H-pyrrol-3-yl]-N-metilmetanamin; 8-[{2,6-dimethylbenzyl}amino]-N-[2-hydroxyethyl]-2,3-dimetilimidazo[1,2-a]pyridine-6-carboxamide; 5,6-dimethyl-2-(4-fluoro-phenylamino)-4-(1-methyl-1,2,3,4-tetrahydroisoquinoline-2-yl)pyrimidine or pharmaceutically acceptable salts thereof. Invention also relates to pharmaceutical composition containing one of the above compounds.

EFFECT: invention provides normalising and improving gastrointestinal motility.

4 cl, 4 dwg, 4 ex