FIELD: chemistry.
SUBSTANCE: invention relates to a method for producing 2-(2-hydroxy)adamantylalkyl(aryl)ketones of general formula: 
, which are intermediate products during synthesis of possibly biologically active substances. The method involves reaction of adamantanone cyanohydrin with Grignard reagents selected from: ethylmagnesium bromide, benzylmagnesium chloride, alkylmagnesium chloride, in a medium of anhydrous diethyl ether or tetrahydrofuran in molar ratio of reagents equal to 1:2, respectively, at temperature 30-45°C for 2-3 hours, with subsequent treatment of the reaction product with water and acetic acid and extraction of the end product.
EFFECT: high output of end products.
3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING 2-(2-ALKYL(DIALKYL)AMINO)ADAMANTYLALKYL(ARYL)KETONES | 2009 |
|
RU2408570C1 |
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| METHOD OF SYNTHESIS OF α-ADAMANTYL-CONTAINING ALIPHATIC AND SATURATED AROMATIC KETONES | 2000 |
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SU1816763A1 |
| PROCESS FOR PRODUCING 2-ACRYLPROPIONIC ACID | 0 |
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| METHOD OF PRODUCING N-(2-HETEROCYCLOALKYL-1-YLETHYL)ADAMANTANE-2-AMINES | 2013 |
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RU2529201C1 |
| METHOD FOR PRODUCTION OF 2-AMINO-2-CYANOADAMANTANE OR DERIVATIVES THEREOF | 2006 |
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| NOVEL METHOD OF 3-[5'-(3,4-BIS-HYDROXYMETHYLBENZYLOXY)-2'-ETHYL-2-PROPYLBIPHENYL-4-YL]PENTA-3-OL OBTAINMENT | 2005 |
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| METHOD OF PRODUCING 2-AMINOMETHYL ALKYL(ARYL)AMINO ADAMANTANES | 2012 |
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