METHOD OF PRODUCING N-(2-HETEROCYCLOALKYL-1-YLETHYL)ADAMANTANE-2-AMINES Russian patent published in 2014 - IPC C07D295/13 

Abstract RU 2529201 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing N-(2-heterocycloalkyl-1-ylethyl)adamantane-2-amines of general formula: where X = a bond, -CH2-, -O-, which includes alkylation of a heterocycle selected from piperidine, morpholine and pyrrolidine with N-(2-chloroethyl)adamantane-2-amino chlorohydrate, obtained by chlorinating 2-(2-adamantylamino)ethanol with thionyl chloride, with molar ratio of N-(2-chloroethyl)adamantane-2-amino chlorohydrate to the heterocycle of 1:8-10, followed by treatment of the reaction mass with an aqueous alkaline solution and separating the end product.

EFFECT: obtaining novel adamantane amine derivatives with high output and purity.

4 ex

Similar patents RU2529201C1

Title Year Author Number
METHOD FOR PRODUCTION OF 2-AMINO-2-CYANOADAMANTANE OR DERIVATIVES THEREOF 2006
  • Popov Jurij Vasil'Evich
  • Mokhov Vladimir Mikhajlovich
  • Kkhammo Mishel Veniamin
RU2307123C1
HETEROCYCLIC NITROGEN PYRROLE DERIVATIVES, PRODUCING THEM AND PHARMACEUTICAL APPLICATION 2008
  • Tan Pehn Chzho
  • Su Idun
  • Li Jali
  • Chzhan Lehj
  • Chzhao Futsjan
  • Jan Tszjaljan
  • Chzhou In
  • Bieh Pinjan'
  • Tsjan' Guan'Tao
  • Tszjuj Mingan
RU2473543C2
NOVEL DERIVATIVES OF BENZIMIDAZOLE AND THEIR USING AS MEDICAMENTS 2002
  • Puatu Lidi
  • Bro Valeri
  • Ferrandi Ehrik
  • Tjur'O Kristof
RU2294326C2
METHOD OF OBTAINING 2-AMINO-2-CYANOADAMANTANE 2013
  • Popov Jurij Vasil'Evich
  • Mokhov Vladimir Mikhajlovich
  • Tankabekjan Nazeli Arsenovna
RU2523462C1
METHOD OF 2-AMINO-2-CYANOADAMANTANE TRANSAMINATION 2013
  • Popov Jurij Vasil'Evich
  • Mokhov Vladimir Mikhajlovich
  • Tankabekjan Nazeli Arsenovna
RU2523463C1
METHOD OF OBTAINING 2-AMINO-2-CYANOADAMANTANE DERIVATIVES 2013
  • Popov Jurij Vasil'Evich
  • Mokhov Vladimir Mikhajlovich
  • Tankabekjan Nazeli Arsenovna
RU2523461C1
METHOD OF PRODUCING 2-(2-ALKYL(DIALKYL)AMINO)ADAMANTYLALKYL(ARYL)KETONES 2009
  • Popov Jurij Vasil'Evich
  • Mokhov Vladimir Mikhajlovich
  • Tolkacheva Vera Aleksandrovna
  • Safronova Ol'Ga Jur'Evna
RU2408570C1
METHOD OF PRODUCING 2-AMINOMETHYL STYRENES CONTAINING HETEROCYCLIC FRAGMENT 2014
  • Poljanskij Kirill Borisovich
  • Larionova Natal'Ja Andreevna
  • Afanas'Ev Vladimir Vladimirovich
  • Bespalova Natalija Borisovna
RU2562775C1
SUBSTITUTED N-[2-(1-ADAMANTYLAMINO)-2-OXOETHYL]-N-(AMINOALKYL)AMIDES OF NITROBENZOIC ACIDS 2011
  • Seredenin Sergej Borisovich
  • Likhosherstov Arkadij Mikhajlovich
  • Kryzhanovskij Sergej Aleksandrovich
  • Mokrov Grigorij Vladimirovich
  • Stoljaruk Valerij Nikolaevich
  • Vititnova Marina Borisovna
  • Tsorin Iosif Borisovich
  • Gudasheva Tat'Jana Aleksandrovna
  • Sorokina Aleksandra Valerianovna
  • Durnev Andrej Dmitrievich
RU2500666C2
2-PROPEN-1-ONS AS HSP-70 INDUCTORS 2005
  • Kumar Prabkhat
  • Mane Uttam Radzharam
  • Gupta Ramesh Chandra
  • Nadkarni Sunil Sadanand
  • Mokhanan Anookkh
  • Tandon Ruchi
  • Munshi Siralee
RU2341522C2

RU 2 529 201 C1

Authors

Novakov Ivan Aleksandrovich

Orlinson Boris Semenovich

Savel'Ev Evgenij Nikolaevich

Potaenkova Elena Aleksandrovna

Shilin Aleksej Konstantinovich

Dates

2014-09-27Published

2013-06-18Filed