FIELD: chemistry.
SUBSTANCE: invention relates to a novel method of producing 2-aminomethyl alkyl(aryl)amino adamantanes of general formula: ; ; ; R=-NH2, -N(CH3)2, NHNH2, where , -Me, -OMe, by reducing the corresponding 2-alkyl(aryl)amino-2-cyanoadamantanes from the family 2-amino-2-cyanoadamantane, 2-dimethylamino-2-cyanoadamantane, 2-hydrazine-2-cyanoadamantane, 2-cyclohexylamino-2-cyanoadamantane, 2-phenylamino-2-cyanoadamantane, 2-p-methylphenylamino-2-cyanoadamantane, 2-p-methoxyphenylamino-2-cyanoadamantane or 2-(2-phenyl)-N-ethylamino-2-cyanoadamantane with lithium aluminium hydride in the medium of tetrahydrofuran while heating and stirring for 2.5-5 hours with molar ratio 2-alkyl(aryl)amino-2-cyanoadamantane:lithium aluminium hydride of 1:2 at 65-67°C.
EFFECT: method enables to obtain novel adamantane derivatives with high output.
1 cl, 8 ex
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Authors
Dates
2013-06-10—Published
2012-03-26—Filed