PYRIDYL DIMETHYLSULPHONIC DERIVATIVE Russian patent published in 2010 - IPC C07D213/61 C07D213/48 C07D213/79 C07D213/81 C07D401/04 A61K31/4409 A61P25/28 

FIELD: chemistry.

SUBSTANCE: invention relates to novel compound of general formula (I): , where Ar₁ is a phenyl group substituted with 1-3 halogen atoms; Ar₂ is a phenyl group which can be substituted with a halogen, alkoxyalkyl, alkoxyhalogenalkyl, or pyridyl group which can be substituted with halogenalkyl; X is -S-, -SO- or -SO₂-; Y is a hydrogen atom, -NR¹R² (where R¹ is a hydrogen atom, lower alkyl group or hydroxy group; and R² is a hydrogen atom, lower alkyl group which can be substituted, lower alkanoyl group, alkoxycarbonyl group which can be substituted, lower alkoxy group which can be substituted, amino group which can be substituted; or R¹ and R² together with a nitrogen atom with which they are bonded form a piperidine, morpholine, azetidine or piperazine ring, which can be substituted wiht a hydroxy group) or -OR¹', where R¹ is a hydrogen atom); Z is an oxygen atom or sulphur atom; and R is a hydrogen atom or a lower alkyl group; or to salts thereof. The invention also relates to a medicinal agent and a pharmaceutical composition which inhibit production/secretion of β- amyloid protein, to use of said compounds to prepare a medicinal agent and to a method of treating diseases caused by abnormal production or secretion of β- amyloid protein.

EFFECT: novel compounds which can inhibit production/secretion of β- amyloid protein and which can be used in treating Alzheimer disease or Down syndrome are obtained and described.

30 cl, 136 ex, 1 tbl