FIELD: medicine.
SUBSTANCE: invention is implemented by using a microorganism expressing an immunomodulatory compound combined with an antigen in the form of a drug, therapeutic foodstuff or nutraceutical for induction of immune tolerance or treatment of an immune response associated disease. Particularly, the invention discloses induction of regulatory T-cells producing Foxp3+ and/or IL-10, and/or TGF-β which are able to suppress undesired immune antigen responses by oral delivery of said antigen combined with a microorganism secreting immunosuppressive cytokine. Described is a method of induction of immune antigen tolerance in an animal and a method of treating the immune response associated disease by mucosal delivery of the antigen combined with the microorganism, expressing the immunomodulatory compound. Also, described is the drug, nutraceutical or therapeutic foodstuff for treatment, prevention and/or relief of the immune response associated disease.
EFFECT: use of the invention provides more effective immunosuppression.
25 cl, 12 dwg, 6 ex
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