BRIDGED N-CYCLYC SULPHONAMIDO-INHIBITORS OF GAMMA-SECRETASE Russian patent published in 2011 - IPC C07D471/18 C07D471/22 C07D487/18 C07D487/22 A61K31/63 A61P25/28 

Abstract RU 2422443 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: there are described new N-cyclic sulphonamido-compounds and their pharmaceutically acceptable salts of formula : of formula 1a of formula 1b of formula 1c where the ring A means phenyl, thienyl which can be substituted by halogen, or pyridinyl; a value of the ring B is presented in the patent claim, and also a pharmaceutical composition containing them, and a method of treating Alzheimer's disease.

EFFECT: compounds are gamma-secretase inhibitors and can be used for treating Alzheimer's disease.

16 cl, 98 ex

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RU 2 422 443 C2

Authors

Bauehrs Simeon

Garofehlo Al'Bert V.

Khom Roj K.

Konradi Andrej V.

Mattson Mehtt'Ju N.

Nehjtzel Martin L.

Semko Kristofer M.

Truong An' P.

U Tszin

Ksu Jing-Zi

Dates

2011-06-27Published

2006-08-18Filed