HETEROCYCLIC COMPOUNDS, EFFECTIVE FOR KINASE INHIBITION Russian patent published in 2018 - IPC C07D403/12 C07D401/12 C07D413/12 C07D487/22 C07D487/04 C07D417/12 C07D471/04 C07D413/14 A61K31/4245 A61K31/433 A61K31/4427 A61K31/4439 A61K31/506 A61K31/4709 A61K31/517 A61K31/519 A61K31/437 A61P35/00 

Abstract RU 2640862 C2

FIELD: pharmacology.

SUBSTANCE: invention relates to a compound of formula

(I)

or a pharmaceutically acceptable salt thereof, wherein Q is O; W is phenyl; X is absent; Y is NH; Z1 and Z2 are N; Z3 is NR5, where R5 is hydrogen; R1 is pyridine or pyrimidine; optionally substituted with C1-C6alkyl, C1-C6alkoxy, -NR10R11 or -SOmR12, where R10 and R11 are hydrogen, R12 is C1-C6alkyl; and m is 0; R3 is C1-C6alkyl; R2 is C1-C6alkyl when p is 1; or one R2 is C1-C6alkyl and one R2 is halogen when p is 2; or one R2 and R3 combined with formation of a five- to seven-membered carbocycle; R4 is hydrogen; p=1 or 2; and n is 1.

EFFECT: heterocyclic compounds designed for cancer treatment.

12 cl, 1 tbl, 8 ex

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RU 2 640 862 C2

Authors

Arnold Lee Daniel

Murphy Eric A.

Dates

2018-01-18Published

2011-03-24Filed