NEW PHOSPHORUS-CONTAINING THYMOMIMETIC DRUGS Russian patent published in 2011 - IPC C07F9/38 C07F9/40 C07F9/44 C07F9/655 A61K31/66 A61P3/04 A61P3/10 

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to compounds of formula VIII suitable in medicine as T3 mimetic drugs: VIII, where G is O, -S(=O)₂- or -CH₂-; R² is halogen, alkyl, -CF₃, -OCF₃, alkoxy or cyano; R³ and R⁴ are H, halogen, alkyl or -(CR^a ₂)_maryl; T is selected from -(CR^a ₂)_k-, -CR^b=CR^b-(CR^a ₂)_n-, -(CR^a ₂)_n-CR^b=CR^b, -(CR^a ₂)-CR^b=CR^b-(CR^a ₂)-, O(CR^a ₂)(CR^a ₂)_n-, -S(CR^a ₂)(CR^a ₂)_n-, -N(R^c)(CR^b ₂)(CR^a ₂)_n-, -N(R^b)C(O)(CR^a ₂)_n-, -(CR^a ₂)_nCH(NR^bR^c) -C(O)(CR^a ₂)_m-, -(CR^a ₂)_mC(O)-, -(CR^a ₂)C(O)(CR^a ₂)_n-, -(CR^a ₂)_n C(O)(CR^a ₂)- and -C(O)NH(CR^b ₂)(CR^a ₂)_p-; R^a, R^b, R^c, R¹, R⁶, R⁷, R⁸ and R⁹ are H, halogen or alkyl; or R⁶ and T with C atom form a 5-6-members ring with 0-2 groups -NRⁱ-, -O- or -S-; Rⁱ is H, -C(O)alkyl, alkyl or aryl; R⁵ is OH, alkoxy, -OC(O)R^e, -OC(O)OR^h, -F, -NHC(O)R^e, -NHS(=O)R^e, -NHS(=O)₂R^e, -NHC(S)NH(R^h) or -NHC(O)NH(R^h); R^e is alkyl, -(CR^a2)_n-aryl, -(CR^a ₂)_n-cycloalkyl or -(CR^a ₂)_n- heterocycloalkyl; R^h is H or alkyl; X is P(O)YR^llY'R^ll; Y and Y' are O or -NR^v-; R¹¹ is H, alkyl, -C(R^z)₂-OC(O)R^y, -C(R^Z)₂-O-C(O)OR^y, -alkyl-S-C(O)R^y, -[C(R^z)₂]_q-COOR^y, -cycloalkylene-COOR^y, aryl, -C(R^z)₂OC(O)SR^y, -C(R^x)₂COOR^y or two R¹¹ and R¹¹ form a cycle; k is within 1 to 4; m is within 0 to 3; n is within 0 to 2; p is within 0 to 1; q is 2 or 3; R^v, R^z, R^y and R^x are H or alkyl, or two R^x and R^x form a cycle.

EFFECT: production of new thymomimetic drugs.

19 cl, 80 ex, 10 tbl, 13 dwg