FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to field of pharmaceutical industry, in particular to method of obtaining system of targeted drug delivery for introduction of pharmaceutically active substance into central nervous system of mammals through hematoencephalic barrier. System contains poly(DL-lactide) and/or poly(DL-lactide-soglycolide)-based nanoparticles, pharmacologically active substance, absorbed, adsorbed and/or included into nanoparticles, and contains TPGS or has coating from surface-active substance pluronic 188, which is precipitated on drug-filled nanoparticles. Described are methods of obtaining system of targeted drug delivery and application of system of targeted drug delivery for treatment of CNS disease or disorder.
EFFECT: elaboration of efficient method of obtaining system of targeted drug delivery for introduction of pharmacologically active substance into central nervous system of mammals through hematoencephalic barrier.
20 cl, 14 ex, 2 dwg
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