METHOD OF PRODUCING A PHARMACEUTICAL COMPOSITION CONTAINING PENTOXIFYLLINE Russian patent published in 2019 - IPC A61K9/14 A61K31/519 A61K47/30 A61P7/00 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention refers to pharmaceutical industry and can be used for producing a dosage form of pentoxifylline of prolonged action. Active substance is presented in the form of microparticles, for the formation of which D,L-lactide-co-glycolide and polyvinyl alcohol are used. Active substance used is pentoxifylline, which together with D,L-lactide-co-glycolide containing poly-D,L-lactic and polyglycolic acids in molar ratio of 50:50, is dissolved in chloroform, obtained solution is introduced into 3 % aqueous solution of polyvinyl alcohol with constant stirring with the help of a homogeniser at rate of 20,000 rpm, followed by washing and separation by centrifugation of formed microparticles with particle size of 300 ± 50 nm.

EFFECT: invention provides preparing a long-acting pentoxifylline formulation with an antithrombotic effect for 24 hours.

1 cl, 2 dwg, 1 tbl, 4 ex