FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to novel complexes of Platelet-Derived Growth Factor (PDGF), associated with amphiphilic polymers, ensuring physical and chemical stability of protein in respect of decomposition at physiological pH in vitro for application in pharmaceutics. Complex amphiphilic polymer-PDGE possesses chemical and physical stability, is water-soluble, polymer being selected from polysaccharides. Polymer consists of hydrophilic polymer skeleton, functionalised by hydrophobic substituents and hydrophilic groups. Invention also relates to method of obtaining complex amphiphilic polymer-PDGE, which is obtained in water medium in absence of organic solvent, able to denature protein, and to application of said complex amphiphilic polymer-PDGE for obtaining therapeutic composition with healing action, intended for treatment of ulcers by topic application.
EFFECT: improvement of physical and chemical stability of therapeutic protein in vitro and in vivo.
17 cl, 3 ex
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