FIELD: medicine, pharmaceutics.
SUBSTANCE: present invention refers to new polysaccharide protein derivatives, particularly insulin where polysaccharide is polysialic acid containing 20 to 125 units of sialic acid and where at least 85 % of insulin derivatives are modified on a N-tail of insulin B-chain only, and also to methods of producing it.
EFFECT: invention provides higher stability, prolonged biological half-life, lower insulin immunogenicity, and can find application in pharmaceutical compositions for diabetes treatment.
3 tbl, 15 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| ALDEHYDE DERIVATIVES OF SIALIC ACID, METHODS OF THEIR OBTAINMENT, CONJUGATES OF ALDEHYDE DERIVATIVES OF SIALIC ACID, AND PHARMACEUTICAL COMPOSITION BASED ON THEM | 2004 |
|
RU2333223C2 |
| POLYSIALIC ACID DERIVATIVES | 2004 |
|
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| GLYCOPOLYSIALYLATION OF PROTEINS, WHICH ARE NOT BLOOD CLOTTING PROTEINS | 2010 |
|
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| GLYCOPOLYSIALYLATION OF PROTEINS THAT ARE NOT THE PROTEINS OF THE BLOOD CLOTTING | 2014 |
|
RU2662807C2 |
| CONJUGATES OF BLOOD COAGULATION PROTEINS | 2010 |
|
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| BLOOD COAGULATION PROTEIN CONJUGATES | 2010 |
|
RU2744370C2 |
| METHOD OF REDUCING CONTENT OF ENDOTOXIN IN SAMPLE CONTAINING POLYSIALIC ACID AND ENDOTOXIN | 2008 |
|
RU2473567C2 |
| HUMAN OXYNTOMODULIN, ITS APPLICATION, MEDICATION BASED THEREON AND METHOD OF APPLYING MEDICATION FOR TREATMENT AND PREVENTION OF HYPERGLYCEMIA | 2009 |
|
RU2524204C2 |
| METHOD OF POLYSIALYLATED HUMAN INSULIN PURIFICATION | 2015 |
|
RU2736358C2 |
| DRUG PREPARATION AND METHOD FOR IMPROVING RHEOLOGICAL PROPERTIES OF SPUTUM AND PULMONARY ADMINISTRATION OF THIS PREPARATION | 2009 |
|
RU2522846C2 |
