RENNIN INHIBITOR SYNTHESIS WITH USING CYCLOADDITION REACTION Russian patent published in 2011 - IPC C07D207/16 C07C237/22 C07C251/24 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a method of producing compounds of formula IV in which R means hydrogen, alkyl or alkoxyalkyl, preferentially C₁-C₇alkyl, especially methyl; R₁ means hydrogen, alkyl or alkoxyalkyl, preferentially C₁-C₇-alkoxy-C₁-C₇-alkyl, especially 3-methoxypropyl; R' means hydrogen, alkyl or arylalkyl, preferentially C₁-C₇-alkyl, C₁-C₃-alkylphenyl, more preferentially C₁-C₄-alkyl or benzyl, especially ethyl; R₂ means alkyl, or its salts which involves introduction of the compound of formula III where R, R₁ and R' are such as specified here for the compound of formula IV, into a cycloaddition reaction with α,β-unsaturated carbonyl system of formula (V) where R₂ is such as specified for the compound of formula IV above. Also, the invention refers to the application of the compound of formula III, to the compounds of formula IV, to a method of producing the compounds of formula VI, to the compounds of formula VI, and also to a method of producing the compound of formula XXIII.

EFFECT: development of the new method of producing the compound of formula XXIII applicable for synthesis of pharmaceutically active compounds, rennin inhibitors.

13 cl, 1 ex