PYRAZOLE- AND PHENYL DERIVATIVES AS PPAR INHIBITORS Russian patent published in 2010 - IPC C07D231/12 A61K31/41 A61K31/415 A61P3/04 A61P3/06 A61P3/10 

Abstract RU 2384573 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a novel compounds of formula (I) and their pharmaceutically acceptable salts or esters having agonistic effect on PPARδ and/or PPARα, where X1 is selected from a group which includes O and CH2, R1 denotes hydrogen or C1-C7alkyl, R2 denotes C1-C7alkyl, or if X1 denotes CH2, then R2 denotes hydrogen, R3 denotes hydrogen or C1-C7alkyl, R4 and R8 are independently selected from a group which includes hydrogen, C1-C7alkyl, C1-C7alkoxy, halogen, R5, R6 and R7 are independently selected from a group which includes hydrogen, C1-C7alkoxy, halogen, where one of R5, R6 and R7 denotes , where X2 denotes O, R10 denotes hydrogen, R11 denotes hydrogen, one of R12 or R13 is selected from a group which includes hydrogen, C1-C7alkyl and fluoro(C1-C7)alkyl, and the other denotes an unshared electron pair, R14 denotes hydrogen, R15 denotes 4-trifluoromethoxyphenyl, and n equals 1, 2 or 3. The invention also relates to pharmaceutical compositions containing such compounds.

EFFECT: increased effectiveness of the compounds.

23 cl, 20 ex

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RU 2 384 573 C2

Authors

Akkermann Zhan

Ehbi Iogannes

Bindzheli Al'Fred

Greter Uve

Irt Zhorzh

Kun Bernd

Mehrki Khans-Peter

Mejer Markus

Mor Peter

Rajt Matt'Ju Blejk

Dates

2010-03-20Published

2005-04-20Filed