FIELD: biotechnology.
SUBSTANCE: invention refers to molecular genetics, biotechnology and medicine. Disclosed is a recombinant vector for producing plasmid genetic constructs having high length of expression of target genes containing hexamer of a modified S/MAR element from an IFNβ human gene and reduced to 13 number of CpG dinucleotides, nucleotide sequence of which is presented in SEQ ID NO 1.
EFFECT: invention provides effective and prolonged expression of target genes built into vector pMBR2 for use in ex vivo modification of cells for the purpose of cell therapy and gene therapy by direct introduction of genetic structures in target tissues.
1 cl, 9 dwg, 7 ex
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