METHOD OF PREDICTING RISK OF DEVELOPMENT OF ABNORMAL UTERINE BLEEDINGS IN PUBERTY PERIOD IN TEENAGE GIRLS Russian patent published in 2011 - IPC A61B10/00 G01N33/48 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to gynecology, and can be used for prediction of risk of development of abnormal uterine bleedings in puberty period in teenage girls. For this purpose weight is determined (Ves), weight 45 kg and lower is designates as 1, from 46 to 48 kg - as 2, from 49 to 52 kg - as 3, from 53 to 62 kg - as 4; from 62 to 68 kg - as 5; 68 kg and higher- as 6. Height (Rost) is measured, height 154 cm and lower is designated as 1, from 155 to 157 cm - as 2; from 158 to 161 cm - as 3; from 162 to 170 cm - kas 4; from 171 to 173 cm - as 5; from 174 cm and higher - as 6. Pinch test (Proba) is carried out, negative test is designated as 1, positive - as 2. Varga index is determined, norm is designated as 1; moderate body weight reduction as 2; body weight deficit - as 3. In urine concentration of total hydroxyproline is determined in mcmol/l (OGOP); concentration of bound hydroxyproline in mcmol/l (SV-GOP) are determined. In blood concentration of luteinising hormone in mIU/ml (LG); concentration of estradiol in ng/ml (ESTROD); concentration of thyrotropic hormone in ng/ml (TTG); concentration of antibodies to thyroid peroxidase in unit/ml (AT-TPO) are determined. Obtained results of examination are substituted into mathematical prognostic models: Model 1= Ves*9.7489-Rost*2.4950+Proba*2.3133+Index*14.2906-SV-GOP*0.0437+OGOP*0.1088-LG*0.1261+ESTROD*0.2678+TTG*0.8120-AT-TPO*0.0338-47.8720; Model 2 =Ves* 10.3679-Rost*2.5602+Proba*4.4430+Index*16.2118-SV-GOP*0.0730+OGOP*0.1490-LG*0.8682+ESTROD*0.2128+TTG*1.4743-AT-TPO*0.1035-55.7844. From two obtained values the larger one is selected. If larger value is obtained in model 1, low risk of uterine bleedings development is predicted. If larger value is obtained in model 2, high risk is predicted.

EFFECT: method ensures increased accuracy of prediction of risk of abnormal uterine bleedings development in puberty period.

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