FIELD: medicine.
SUBSTANCE: antibody under the invention is produced from Nicotiana benthamiana leaves by transient transfection of expression vectors. It represents immunoglobulin G and a tetramer consisting of two light and two heavy peptide chains and them larger supramolecular assemblies. The antibody is recovered both in the glycated, and in non-glycated form. The antibody is capable to bind selectively HER2/neu protein, to inhibit cancer cell proliferation. Using the antibody under the invention enables diagnosing HER2-positive breast cancer.
EFFECT: invention can be used for preparing drugs and diagnostic agent for breast cancer.
8 dwg, 4 ex
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Authors
Dates
2011-08-10—Published
2010-04-09—Filed