ANTIBODY SPECIFICALLY REACTING WITH HER2/neu ONCOPROTEIN Russian patent published in 2011 - IPC C07K16/18 A61K39/395 A61P35/00 C12N5/10 

Abstract RU 2425840 C1

FIELD: medicine.

SUBSTANCE: antibody under the invention is produced from Nicotiana benthamiana leaves by transient transfection of expression vectors. It represents immunoglobulin G and a tetramer consisting of two light and two heavy peptide chains and them larger supramolecular assemblies. The antibody is recovered both in the glycated, and in non-glycated form. The antibody is capable to bind selectively HER2/neu protein, to inhibit cancer cell proliferation. Using the antibody under the invention enables diagnosing HER2-positive breast cancer.

EFFECT: invention can be used for preparing drugs and diagnostic agent for breast cancer.

8 dwg, 4 ex

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RU 2 425 840 C1

Authors

Dorokhov Jurij Leonidovich

Komarova Tat'Jana Valer'Evna

Kosorukov Vjacheslav Stanislavovich

Dates

2011-08-10Published

2010-04-09Filed