METHOD OF OBTAINING POROUS MATRIX Russian patent published in 2011 - IPC A61K9/00 A61L27/14 A61L27/50 A61F2/02 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to application in biomedicine, cell technologies, substituting and restorative surgery, in particular for manufacturing matrix-carrier, implanted together with cells into human organism in order to restore functioning of affected organ. Method lies in preparation of solution of polyoxybutirate-polyoxyvalerate (POB/POV) in dichloroethane, after which into solution introduced is icy acetic acid with the following component ratio, g: POB/POV - 1-2, dichloroethane- 10-12, icy acetic acid - 10-15; obtained solution is frozen in form at temperature minus (25-30)°C and sublimation drying of obtained semi-product of matrix is performed in vacuum chamber. Freezing of solution and sublimation drying of obtained semi-product of matrix are performed on padding, made from polytetrafluorethylene fiber and plate from water ice. Thickness of water ice plate is selected on condition of its complete sublimation during drying in vacuum chamber, sublimation drying of matrix semi-product on padding being performed on mesh from plastic threads. Initial pressure in vacuum chamber must be not lower than 100 Torr, and after dichloroethane evaporation from matrix semi-product pressure in vacuum chamber is reduced to ~0.01 Torr. Polymer matrix with bimodal structure of simply connected pores is produced.

EFFECT: simplification and cheapening of technology due to refuse from low temperature of performing vacuum sublimation drying.

7 cl, 4 dwg