TOFA ANALOGUES, APPLICABLE IN TREATMENT OF DERMATOLOGICAL DISORDERS OR CONDITIONS Russian patent published in 2015 - IPC C07D307/68 C07D405/12 C07D407/12 A61K31/341 A61P17/06 A61P17/10 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention describes analogues of 5-(tetradecyloxy)-2-furoic acid (TOFA) of formula , where R¹ represents -O-R², R² independently represents heterocyclylalkyl or halogenalkyl; or R¹ represents -O-R³-C(O)N(R⁵)R⁶, each R³ represents alkylene chain and R⁴ represents optionally substituted alkyl or optionally substituted phenyl, each R⁵ independently represents hydrogen, alkyl or cycloalkyl and each R⁶ represents alkyl, cycloalkyl, benzyl or -R³-C(O)OR⁴; or any R⁵ and R⁶ together with nitrogen atom, which they are both bound to, form optionally substituted N-heterocyclyl, or its pharmaceutically acceptable salts.

EFFECT: invention relates to pharmaceutical compositions for treatment of dermatological disorders or conditions, characterised by hyperactivity of sebaceous glands, such as acne and greasy skin, and other dermatological disorders and conditions, containing TOFA analogues and pharmaceutically acceptable excipient for dermatological or peroral introduction.

24 cl, 3 dwg, 6 tbl, 33 ex