AMINOINDANE DERIVATIVE OR SALT THEREOF Russian patent published in 2011 - IPC C07C211/42 C07C215/42 C07C215/44 C07C217/52 C07C255/58 C07D295/12 C07D307/82 C07D333/78 A61K31/13 A61K31/381 A61K31/404 A61K31/4453 A61P25/16 

FIELD: chemistry.

SUBSTANCE: invention relates to novel aminoindane derivatives of formula (Ia) or pharmaceutically acceptable salts thereof, which have NMDA receptor antagonist effect, and can be used to prepare a medicinal agent for treating dementia. In formula (Ia):

,

R¹ is a lower alkyl, C₅-C₆ cycloalkyl, phenyl which can be substituted with OH, lower alkyl, halogen atom, O-alkyl, C₅-C₆ heteroaryl containing a S atom as a heteroatom, or lower alkyl substituted with one or more halogen atoms, R² and R³ are identical or different, each denoting alkyl or phenyl, R⁴ and R⁵ are identical or different and each denotes a hydrogen atom, lower alkyl, -O-lower alkyl, -lower alkylene-OH or -lower alkylene-O-lower alkyl, R⁶-R⁹ are identical or different and each denotes a hydrogen atom, lower alkyl, -O-lower alkyl, halogen atom, lower alkyl substituted with one or more halogen atoms, OH, CN, lower alkenyl or nitrogen-containing C₅-C₆ heterocyclic group, R¹⁰ and R¹¹ are identical or different and each denotes a hydrogen atom or lower alkyl. The invention also relates to a pharmaceutical composition containing the said compounds.

EFFECT: improved properties of the derivative.

6 cl, 15 tbl, 130 ex