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2 429 230

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(51)

IPC

C07D213/02(2006-01-01)

A61K31/4406(2006-01-01)

A61K31/455(2006-01-01)

A61K31/14(2006-01-01)

(21) (22)

Application

2010121683/15, 2010-05-27

(24)

Start date

2010-05-27

(22)

Actual filing date

2010-05-27

(45)

Published

2011-09-20

(72)

Inventor

Sysoljatin Sergej ViktorovichSakovich Gennadij ViktorovichKrjukov Jurij AndreevichRogova Alla IvanovnaBubelo Vladimir DmitrievichChernov Anatolij Ivanovich

(73)

Holder

Uchrezhdenie Rossijskoj Akademii Nauk Institut Problem Khimiko-Ehnergeticheskikh Tekhnologij Sibirskogo Otdelenija Ran So Ran)

METHOD OF PRODUCING N-METHYL-4-BENZYLCARBAMIDOPYRIDINIUM IODIDE Russian patent published in 2011 - IPC C07D213/02 A61K31/4406 A61K31/455 A61K31/14

Abstract RU 2429230 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing N-methyl-4-benzylcarbamidopyridinium iodide (MBI), which is used as substance in medicinal agents, involving reaction of isonicotinic acid with benzylamine at temperature 160-185°C and molar ratio 1.0:1.2 and alkylation of the obtained benzylamide of isonicotinic acid with methyl iodide at 40-50°C and molar ratio 1.0:1.2.

EFFECT: high output of the end product and low solvent consumption.

2 cl, 2 tbl, 10 ex

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RU 2 429 230 C1

Authors

Sysoljatin Sergej Viktorovich

Sakovich Gennadij Viktorovich

Krjukov Jurij Andreevich

Rogova Alla Ivanovna

Bubelo Vladimir Dmitrievich

Chernov Anatolij Ivanovich

Dates

2011-09-20—Published

2010-05-27—Filed