FIELD: pharmaceutical chemistry.
SUBSTANCE: group of inventions includes a compound of formula (I) or a pharmaceutically acceptable salt thereof, as well as a pharmaceutical composition based on it. In formula (I) , A is a pyridine ring; Z is CH; R1 is selected from the group consisting of heterocycloalkyl, heterocycloalkyloxy, heterocycloalkyl-C1-6-alkoxy, 6–10-membered heterospirocycloalkyl containing 1–2 heteroatoms selected from oxygen and nitrogen, C3–6-cycloalkyl-C1–6-alkoxy, where heterocycloalkyl is a 4–6-membered heterocycloalkyl containing 1–2 heteroatoms selected from oxygen and nitrogen, and the nitrogen atom in heterocycloalkyl is optionally substituted with C 1–6 -alkyl; R2 is selected from the group consisting of halo and C1–6 haloalkyl; R3 is C1–6 alkyl.
EFFECT: using a compound of formula (I) as an inhibitor of PDGFR kinase activity, in particular PDGFR kinasesα and/or PDGFRβ.
12 cl, 5 dwg, 2 tbl, 45 ex
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