METHOD FOR ASSESSMENT OF RENAL SURVIVAL RATE IN PATIENTS WITH CHRONIC GLOMERULONEPHRITIS BY INTERLEUKIN GENE POLYMORPHISM VALUES Russian patent published in 2011 - IPC G01N33/574 

Abstract RU 2431149 C2

FIELD: medicine.

SUBSTANCE: DNA is recovered from peripheral venous blood; interleukin gene alleles and genotypes are detected. Decreasing renal survival rate in patients with chronic glomerulonephritis is concluded in the following cases: - detection of carriage of interleukin 1A -889C/T IL-1A gene allel-889S or interleukin 10-592C/AIL-10 gene allel-592A; - detection of carriage of interleukin 1 B -511 C/T IL-1B gene allel-51 IT in a combination with nephrotic syndrome for the first examination and observed arterial hypertension during CGN; - detection of 4R/4R genotype of interleukin 1 VNTR IL-lRa receptor antagonist gene.

EFFECT: use of the method allows eliminating further clinical course of chronic glomerulonephritis that gives the chance for early clinical prognosis and developed therapeutic strategy of the given disease.

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RU 2 431 149 C2

Authors

Churnosov Mikhail Ivanovich

Kalmykova Elena Vasil'Evna

Nekipelova Elena Vasil'Evna

Dates

2011-10-10Published

2009-01-19Filed