DIFFERENTIAL DIAGNOSTIC TECHNIQUE FOR FORMS OF ACUTE INFLAMMATORY POLYNEUROPATHY AND CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY WITH ACUTE ONSET Russian patent published in 2011 - IPC A61B5/488 G01N33/48 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to neurology, infectious diseases, clinical immunology. It involves electric neuromyographic, clinical and clinical-biochemical examinations. If observing in the patient 6-9 of the 9 following signs: electric neuromyography showing signs of generalised primary axonal motor and sensory nerve disorder, age 46-60 years old, the presence of associated cardiovascular diseases, the absence of an indicated previous acute enteric infection, a level of haemoglobin less than 132 g/l, erythrocyte count 3.7*10¹²/l or less, alkaline phosphatase level more than 177 Un/l, CD 19+ lymphocytes count less than 0.19*10⁹/l, IgA level more than 1.7 g/l, acute motor-sensor axonal neuropathy is diagnosed. If observing 4-9 of the 9 following signs: electric neuromyography showing signs of generalised, mainly motor, neural level of primary axonal disorder, age 60 years old and more, the presence of associated thyroid disease, the presence of a previous acute enteric infection one month ago and later, anti-GM_I level 70 % and more, anti-Gd_Ib level 90 % and more, a rheumatoid factor 5 IU/ml and more, IgE level less than 40 IU/ml, CD16+/CD56+ lymphocyte count 7 % and less, acute motor axonal neuropathy is diagnosed. If observing 2-4 of the 4 following signs: electric neuromyography showing signs of initially demyelinating process in peripheral nerves, IgM level more than 24 g/l, CD3+/HLA-DR+ lymphocyte count more than 2.0 %, IgE level more than 60 IU/ml, acute inflammatory demyelinating polyneuropathy is diagnosed. If observing 4-5 of the 5 following signs: anti-GM₂ level 6 % and less, monocyte count more than 8.5 %, aspartate aminotransfrerase level 36 Un/l and less, IgA level 0.8 g/l less, detection of blood HSV type II IgM, chronic inflammatory demyelinating polyneuropathy with acute onset is diagnosed.

EFFECT: technique extends the range of products for differential diagnostics of forms of acute inflammatory polyneuropathy and chronic inflammatory demyelinating polyneuropathy with acute onset.

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