METHOD FOR PREDICTION OF DEVELOPING VITAL DYSFUNCTIONS ACCOMPANYING SEVERE ACUTE INFLAMMATORY POLYNEUROPATHY Russian patent published in 2013 - IPC G01N33/53 G01N33/48 G01N33/68 

FIELD: medicine.

SUBSTANCE: blood serum of a patient with acute inflammatory polyneuropathy is examined by ELISA as shown by a biomarker of neurofilament heavy-chain (NfH), and if the value NfH is more than 0.144 ng/mL, developing respiratory failure requiring artificial pulmonary ventilation (APV) and developing manifested bulbar syndrome requiring tube feeding are predicted. The values NfH falling within the range of 0.094-0.144 ng/mL enable predicting developing manifested bulbar syndrome requiring tube feeding and either developing respiratory failure requiring no artificial pulmonary ventilation (APV), or no respiratory failure. If the value is less than 0.094 ng/mL, either developing bulbar syndrome requiring no tube feeding, or no bulbar disorders, and no respiratory failure are predicted.

EFFECT: use of the declared method enables the high-sensitivity and specificity prediction of developing severe clinical presentations of the disease, such as developing respiratory failure requiring artificial pulmonary ventilation, and bulbar disorders requiring tube feeding on the first days of the disease.

1 tbl, 4 ex