CYCLIC N,N'-DIARYLTHIOUREAS OR N,N'-DIARYLUREAS - ANTAGONISTS OF ANDROGEN RECEPTORS, ANTI-CANCER MEDICATION, METHOD OF OBTAINING AND APPLICATION Russian patent published in 2011 - IPC C07C275/32 C07D233/86 C07D233/56 C07D471/10 C07D491/107 A61K31/27 A61K31/513 A61K31/4166 A61K31/4188 A61K31/527 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: claimed invention relates to novel cyclic N,N'-diarylthioureas or N,N'-diarylureas of general formula (1), their optic (R)- and (S)-isomers and their pharmaceutically acceptable salts - antagonists of androgenic receptors. In formula (1), where: X represents oxygen or sulfur atom; m=0 or 1, mR1 represents C₁-C₃alkyl; R2 and R3 represent hydrogen atom; or R2 and R3 together with carbon atom, to which they are bound, form group C=O; or represents group NH; R4 and R5 represent hydrogen atom; or R4 represents hydrogen atom, and R5 represents methyl; or R4 represents hydrogen atom, methyl, and R5 represents group Z_n-Y-R6, in which n=1 or 2, Z represents CH₂ or C=0 and Y- oxygen atom or N-CH₃, or Y represents C=O, and Z represents CH₂; R6 represents hydrogen atom, methyl, benzyl, hydroxygroup or R5 and R4 together with atoms, to which they are bound, form five or sic-member heterocycle, including, at least, oxygen or nitrogen atom, which can be substituted by methyl. Invention also relates to method of obtaining compounds.

EFFECT: invention relates to anti-cancer substance, pharmaceutical composition, medication and method of treating prostate cancer with application of invention compounds.

12 cl, 6 dwg, 16 ex