FIELD: chemistry.
SUBSTANCE: invention relates to an improved method of producing abacavir of formula (I) or pharmaceutically acceptable salt thereof, involving reaction of a compound of formula (II), (I)
(II), where R denotes H or (C1-C4)-alkyl radical with an inorganic base such as an alkali metal hydroxide in a mixture of (C1-C6)-alcohol and water; and extraction of abacavir of formula (I) in form of a free base or in form of a pharmaceutically acceptable salt by treating said free base with a corresponding acid.
EFFECT: method ensures high degree of conversion without racemation, enables to minimise formation of impurities and considerably shortens reaction time.
19 cl, 10 ex
Title | Year | Author | Number |
---|---|---|---|
METHOD OF PRODUCING ABACAVIR | 2007 |
|
RU2447073C2 |
ENANTIOMERIC COMPOUNDS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 1992 |
|
RU2091386C1 |
METHOD OF SYNTHESIS OF ENANTIOMERIC COMPOUNDS OR THEIR DERIVATIVES | 1990 |
|
RU2068849C1 |
CHLOROPYRIMIDINE INTERMEDIATE COMPOUNDS | 1995 |
|
RU2140913C1 |
SUBSTITUTED PURINE AND 7-DEAZAPURINE COMPOUNDS | 2011 |
|
RU2606514C2 |
4-[2-AMINO-6-(CYCLOPROPYLAMINO)-9H-PURINE-9-YL]-2-CYCLOPENTENE- -1-METHANOL SUCCINATE AS ANTIVIRAL AGENT | 1995 |
|
RU2145324C1 |
4'-SUBSTITUTED NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS AND PRODUCTION THEREOF | 2016 |
|
RU2720811C2 |
PYRAZOLOPYRIMIDINES AND RELATED HETEROCYCLES AS CK2 INHIBITORS | 2010 |
|
RU2607453C2 |
DIDEOXYDIDEHYDROCARBOCYCLIC NUCLEOSIDES, PHARMACEUTICAL COMPOSITION | 1989 |
|
RU2114846C1 |
BENZYLPHENYLCYCLOHEXANE DERIVATIVES AND METHODS OF THEREOF APPLICATION | 2008 |
|
RU2505521C2 |
Authors
Dates
2011-11-27—Published
2007-09-27—Filed