4'-SUBSTITUTED NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS AND PRODUCTION THEREOF Russian patent published in 2020 - IPC A61K38/44 C12N1/20 A61P31/18 

Abstract RU 2720811 C2

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula I or a pharmaceutically acceptable salt thereof, useful in pharmaceutics and medicine:

,

where: R1 is -H, -C(O)R3 or , R2 is -H or -C(O)R4; each of R3 and R4 is independently selected from -(C1-C3alkylene)m-(C6-C10aryl), where aryl is unsubstituted or substituted with substituent R5; m is integer 1; R5 is -C1-C6 alkyl.

EFFECT: what is presented is a novel compound, a based pharmaceutical composition and a method thereof, which are effective for treating and preventing HIV infection.

14 cl, 6 tbl, 4 ex

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RU 2 720 811 C2

Authors

Girijavallabhan Vinay M.

Mclaughlin Mark

Cleator Edward

Kong Jongrock

Gibson Andrew William

Lieberman David R.

Dieguez Vazquez Alejandro

Keen Stephen Philip

Williams Michael J.

Moore Jeffrey C.

Milczek Erika M.

Peng Feng

Belyk Kevin M.

Song Zhiguo Jake

Dates

2020-05-13Published

2016-09-19Filed