p-PHENYLENEDIAMINE DERIVATIVE AS POTASSIUM CHANNEL REGULATOR, METHOD FOR ITS PRODUCTION AND MEDICAL USE Russian patent published in 2021 - IPC C07D471/04 C07D265/30 A61K31/165 A61P25/08 

Abstract RU 2762562 C1

FIELD: pharmaceutics.

SUBSTANCE: present invention relates to a compound represented by the general formula A, in which: when ring B is , ring A is thiophen, when ring B is ring A is benzene ring, R1 is a substituent in ring A and is halogen, R2 is a substituent in ring B and is a hydrogen atom, R3 and R4 are substituents in six-element ring and are independently a hydrogen atom or C1-6-alkyl, Y is CH, Z is (CH2)n, where n is an integer from 1 to 6, R5 is C1-6-alkyl, or its pharmaceutically acceptable salt. A pharmaceutical composition and use of the compound of the formula A for the preparation of a drug are also proposed.

EFFECT: obtaining new organic compounds suitable as potassium channel regulators.

formula A

6 cl, 4 tbl, 20 ex

Similar patents RU2762562C1

Title Year Author Number
BICYCLIC PYRIDINES AND ANALOGUES AS SIRTUIN MODULATORS 2010
  • Ng Pui Ji
  • Blum Charl'Z
  • Makferson Loren
  • Perni Robert B.
  • Vu Chi B.
  • Akhmed Mokhammed Makhmud
  • Dish Dzheremi S.
RU2550821C2
S1P1 AGONIST AND ITS APPLICATION 2017
  • Wu, Lingyun
  • Zhang, Peng
  • Li, Jian
  • Chen, Shuhui
RU2754845C2
SUBSTITUTED AMINO SIX-MEMBER SATURATED HETEROALICYCLES AS LONG-ACTING DPP-IV INHIBITORS 2016
  • Xu, Xinhe
  • Shen, Yu
  • Xiao, Dengming
  • Luo, Hong
  • Peng, Yong
  • Han, Yongxin
  • Zhang, Aiming
  • Yang, Ling
RU2720488C2
ARYLETHER-SUBSTITUTED IMIDAZOQUINOLINES, PHARMACEUTICAL COMPOSITIONS BASED ON THE SAME, METHODS FOR TREATMENT OF VIRAL DISEASES BASED ON THE SAME AND METHODS FOR TREATMENT OF TUMOR DISEASE BASED ON THE SAME 2001
  • Charl'Z Lesli Dzh.
  • Dellaria Dzhozef F.
  • Kheppner Filip D.
  • Merrill Brajon A.
  • Mikelson Dzhon V.
RU2308456C2
HETEROCYCLIC COMPOUNDS, METHOD FOR PRODUCTION THEREOF AND USE THEREOF 2015
  • Tszyan Khualin
  • Van Chzhen
  • Li Tszyanfen
  • Chzhan Zhunsya
  • Khe Yan
  • Lyu Yuntszyan
  • Bi Minkhao
  • Lyu Chzhen
  • Tyan Guankhuej
  • Chen Vejmin
  • Yan Fejpu
  • U Chunkhuej
  • Van Yuj
  • Tszyan Syanzhuj
  • In Tszintszin
  • Van Guan
  • Shen Tszinshan
RU2667498C2
HETEROCYCLIC NITROGEN PYRROLE DERIVATIVES, PRODUCING THEM AND PHARMACEUTICAL APPLICATION 2008
  • Tan Pehn Chzho
  • Su Idun
  • Li Jali
  • Chzhan Lehj
  • Chzhao Futsjan
  • Jan Tszjaljan
  • Chzhou In
  • Bieh Pinjan'
  • Tsjan' Guan'Tao
  • Tszjuj Mingan
RU2473543C2
AZETIDINONE DERIVATIVES AND A METHOD OF THEIR SYNTHESIS 1992
  • Koiti Khirai[Jp]
  • Judzi Ivano[Jp]
  • Khiroo Kojama[Jp]
  • Takakhide Nisi[Jp]
  • Akira Esida[Jp]
  • Kozo Oda[Jp]
RU2047602C1
PYRAZOLAMINOPIRIMIDINE DERIVATIVES AS MODULATORS OF LEUCINE-REPEATING KINASE 2 2013
  • Bejker-Glenn Charlz
  • Berdik Daniel Dzhon
  • Chembers Mark
  • Chan Brajan K.
  • Chen Khuejfen
  • Estrada Entoni
  • Svini Zakari Kevin
RU2637947C2
THIOPHENYL AND PYRROLYL AZEPINES AS SEROTONIN 5HT RECEPTOR LIGANDS AND USE THEREOF 2007
  • T'Jumi L. Natan
  • Bom Dehvid K.
  • Bennani Jussef L.
  • Robardzh Majkl Dzh.
RU2434872C2
AMINOMETHYL-2,3,8,9-TETRAHYDRO-7H-1,4-DIOXINO[2,3-E]-INDOLE-8-ONE COMPOUNDS AND METHOD OF TREATMENT 1996
  • Stehk Gehri Pol
  • M'Jusho Richard Ehrik
  • Bravo Bajron Abel'
  • Kang Jang Khi
RU2178416C2

RU 2 762 562 C1

Authors

Chen, Huanming

Liang, Bo

Dates

2021-12-21Published

2019-05-22Filed