p-PHENYLENEDIAMINE DERIVATIVE AS POTASSIUM CHANNEL REGULATOR, METHOD FOR ITS PRODUCTION AND MEDICAL USE Russian patent published in 2021 - IPC C07D471/04 C07D265/30 A61K31/165 A61P25/08 

Abstract RU 2762562 C1

FIELD: pharmaceutics.

SUBSTANCE: present invention relates to a compound represented by the general formula A, in which: when ring B is , ring A is thiophen, when ring B is ring A is benzene ring, R1 is a substituent in ring A and is halogen, R2 is a substituent in ring B and is a hydrogen atom, R3 and R4 are substituents in six-element ring and are independently a hydrogen atom or C1-6-alkyl, Y is CH, Z is (CH2)n, where n is an integer from 1 to 6, R5 is C1-6-alkyl, or its pharmaceutically acceptable salt. A pharmaceutical composition and use of the compound of the formula A for the preparation of a drug are also proposed.

EFFECT: obtaining new organic compounds suitable as potassium channel regulators.

formula A

6 cl, 4 tbl, 20 ex

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RU 2 762 562 C1

Authors

Chen, Huanming

Liang, Bo

Dates

2021-12-21Published

2019-05-22Filed