METHOD OF PREDICTING RETARDATION OF INTRAUTERINE DEVELOPMENT OF FETUS IN 2-D TRIMESTER IN PATIENTS WITH HIV Russian patent published in 2011 - IPC A61B5/00 G01N33/48 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to obstetrics, and can be used for predicting syndrome of fetus development retardation (SFDR) in the second trimester in patients with HIV. For this purpose carried out is analysis of screening examination of pregnant women infected with HIV in the second trimester. First determined is viral loading (VL), expressed in number of HIV RNA copies in 1 ml of blood plasma. After that, week of gestation age, at which carrying out of chemical therapy began (BegCT) is fixed and number of anti-viral chemical preparations (NumCP) is estimated in points: in case of monotherapy - 1 point, in case of tritherapy - 3 points. Then, on the basis of data of ultrasound and dopplerometric examination presence of feto-placental failure (FPF) is detected, presence of FPF being estimated as 1 point, absence of FPF - as 0 points. After that, by means of polymerase chain reaction presence in blood of accompanying viral pathology (AVP) in form of hepatitis B virus, hepatitis C virus, cytomegalovirus infection, virus of Herpes simplex is detected, presence of AVP is estimated as 1 point, absence of AVI - as 0 points. In addition, determined are mother's constitution (MC) and father's constitution (FC), hypersthenic type is estimated as 0 points, normosthenic type - as 1 point, hyposthenic type - as 2 points. After that, by formula WEIGHT=2901.2-0.001·VL+24.5·BegCT-37.8·NumCP-23.3·FPF-12.3(AVP)-166.2·MC-21.4·FC predicted value of baby's weight at birth is calculated. If obtained value constitutes less than 2800 g, hypotrophy of newborn baby is predicted, if obtained value is more than 2800 g, it is considered that there is no risk of hypotrophy of newborn baby.

EFFECT: being widely available, method provides possibility of timely prediction of SFDR in pregnant women with HIV, which makes it possible to optimise tactics of pregnancy management in case of HIV infection.

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