METHOD FOR EARLY PREDICTION OF FETOPLACENTAL INSUFFICIENCY IN THE BEGINNING OF THE SECOND TRIMESTER OF PREGNANCY Russian patent published in 2021 - IPC A61B5/00 G01N33/48 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to obstetrics and gynecology, and can be used for early detection of risk of developing fetoplacental insufficiency. Three groups of early predictable factors of fetoplacental insufficiency are determined: real pregnancy, obstetric anamnesis and somatic pathology, wherein an increase in the pulsation index PI of any of the uterine arteries in real pregnancy over 2.5 is estimated as 4 points. More than 2 MoM (multiple of median) increase of PAPP-A (pregnancy-associated plasma protein A) is estimated as 1 point, and a less than 0.8 MoM decrease of PAPP-A as 3 points. More than 2 MoM increase of HCG (human chorionic gonadotropin) is estimated as 1 point, and a less than 0.8 MoM decrease of HCG as 2 points. More than 2 but less than 4.3 increase of TSH (thyroid stimulating hormone) is estimated as 1 point, and more than 4.3 increase of TSH as 2 points. 1 point each is assigned if any of the following factors is present: number of nocturnal urination (nocturia) more than 1, early toxicosis of moderate and severe degrees, a more than 4 increase in fibrinogen, less than 110 hemoglobin, 5 or more bloody discharge and sugar, acute infection and exacerbation of chronic infection in I trimester. In an obstetric anamnesis, moderate preeclampsia is estimated as 2 points and severe as 4 points, missed miscarriages or miscarriages before 9 weeks as 1 point each and after 9 weeks as 2 points each, the first pregnancy as 1 point, stillbirth or early neonatal mortality as 3 points, premature birth, fetal growth retardation at the weight of any of the children at birth of 2800 grams or less, the weight of the woman herself at birth of 2800 grams or less as 2 points. In somatic factors each chronic disease is estimated, such as: gastritis, cholecystitis, pyelonephritis, tonsillitis, bronchitis, arterial hypertension, diabetes mellitus, diseases of lower extremity veins and vulva and smoking as 2 points, body mass index, BMI, of more than 30 and less than 40 as 1 point, and BMI over 40 as 2 points, age over 40 as 1 point. At a total score of up to 4, low risk of FPI is predicted. At a total score of 5 to 9, an average degree, at a total score of more than 10, a high degree is predicted.

EFFECT: method allows increasing accuracy and objectivity of predicting FPI, attributing a pregnant woman to a risk group on time and performing activities aimed at improving perinatal outcomes in time in the beginning of the second trimester.

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