FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine and biotechnology and concerns a preparation of 4-hydroxy - 17R - methylincisterol affecting tissue exchange and exhibiting anticancer and hypolipidemic activities and a producer of a biologically active substance of sterol 4-hydroxy - 17R - methylincisterol derivative. Substance of the invention involves submerged Pleurotus ostreatus 1137 (Russian National Collection of Industrial Microorganisms, F-819) fungus cultivation followed by mycelium separation from a culture fluid and recovery from the mycelium by extraction in ethanol at acid value pH of a medium of low-molecular 100 to 500 Da biologically active substances and recovery of sterol 4-hydroxy - 17R - methylincisterol derivative with preset molecular weight, gross formula and structural formula by dichloromethane. The invention also concerns application of Pleurotus ostreatus 1137 (Russian National Collection of Industrial Microorganisms, F-819) strain as a producer of the biologically active substance of sterol 4 - hydroxy - 17R - methylincisterol derivative.
EFFECT: advantage of the invention consists in development of such preparation which is able to modulate manifestations of hypolipidemic activity along with anticancer activity.
3 cl, 7 tbl, 15 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| PREPARATION WITH POLYFUNCTIONAL MEDICAL-BIOLOGICAL ACTIVITY THAT INFLUENCES TISSUE EXCHANGE BASED ON FUNGUS STRAIN Pleurotus ostreatus VKPM F-819 | 2012 |
|
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| PREPARATION INFLUENCING ON TISSUE METABOLISM AND USE OF FUNGUS STRAIN PLEUROTUS 1137 FOR ITS PREPARING | 2001 |
|
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|
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