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(19)

(11)

2 697 090

(13)

(51)

IPC

C07D471/04(2006-01-01)

A61K31/437(2006-01-01)

A61P3/00(2006-01-01)

A61P9/00(2006-01-01)

A61P25/28(2006-01-01)

A61P27/00(2006-01-01)

A61P29/00(2006-01-01)

A61P35/00(2006-01-01)

A61P37/00(2006-01-01)

(21) (22)

Application

2016127440, 2014-12-08

(24)

Start date

2014-12-08

(22)

Actual filing date

2014-12-08

(45)

Published

2019-08-12

(72)

Inventor

Dzhekson Viktoriya ElizabetKroplin BorisLoue Martin AleksanderPorter Dzhon Robert

(73)

Holder

Ucb Biopharma Sprl

TETRAHYDROIMIDAZOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY Russian patent published in 2019 - IPC C07D471/04 A61K31/437 A61P3/00 A61P9/00 A61P25/28 A61P27/00 A61P29/00 A61P35/00 A61P37/00

Abstract RU 2697090 C1

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to a heterocyclic compound of formula (IIA) or a pharmaceutically acceptable salt thereof, where E denotes -CH₂-; Q is -CH₂-, -CH₂O- or -CH₂OCN₂-; Z is hydrogen or methyl; R¹ denotes -SO₂R^a, -COR^d or -CO₂R^d; or R¹ denotes C₁–C₆-alkyl, this group may optionally contain one or three substitutes independently selected from halogen and C₂–C₆-alkoxycarbonyl; R¹² denotes hydrogen; R¹⁵ means halogen; R¹⁶ means halogen; R^a denotes C₁–C₆-alkyl and R^d denotes trifluoromethyl or C₁–C₆-alkyl. Invention also relates to a pharmaceutical composition based on the compound of formula (IIA), use of the compound of formula (IIA) and a method of treating and/or preventing rheumatoid arthritis or Crohn's disease.

EFFECT: technical result: obtaining novel heterocyclic compounds having the properties of a TNFα activity modulator.

5 cl, 9 ex

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RU 2 697 090 C1

Authors

Dzhekson Viktoriya Elizabet

Kroplin Boris

Loue Martin Aleksander

Porter Dzhon Robert

Dates

2019-08-12—Published

2014-12-08—Filed