FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to organic chemistry, more specifically to a method of olanzapine purification which involves mixing olanzapine with an organic acid in an organic solvent or a mixture of organic solvents to prepare acid-additive olanzapine salt, precipitation and isolation of acid-additive olanzapine salt and transforming acid-additive olanzapine salt in olanzapine; the organic acid is carboxylic acid which is selected from the group including oxalic, fumaric and benzoic acid.
EFFECT: invention refers to methods for producing pure olanzapine, intermediate products and acid-additive olanzapine salts which in turn can find application for producing pure olanzapine used for preparing a drug for treating mental disorders and conditions.
38 cl, 1 tbl, 25 ex
Title |
Year |
Author |
Number |
2-METHYL -10-(4- METHYL-1-PIPERAZINYL) -4H-THIENO- [2,3-B]-[1,5] -BENZODIAZEPINE AND ITS ACID-ADDITIVE SALT, 4-AMINO -2-METHYL -10H-THIENO -[2,3-B]-[1,5] -BENZODIAZEPINE |
1992 |
- Dzhiban Kumar Chakrabarti[In]
- Terrense Majkl Khotten[Gb]
- Dehvid Ehdvard Tapper[Gb]
|
RU2043992C1 |
[(ARYLALKYLPIPERIDINYL-4-YL)-METHYL]-2A,3,4,5-TETRAHYDRO-1-ONES OR THEIR ACID-ADDITIVE SALTS AND A METHOD OF THEIR PREPARING |
1992 |
- Rehjmond V.Kosli Ml.[Us]
- Bettina Shpal'[Us]
|
RU2043989C1 |
METHOD OF OBTAINING THIENO(1,5)-BENZODIAZEPINES OR SALTS THEREOF |
0 |
- Dzhiban Kumar Chakrabarti
- Devid Edvard Tapper
|
SU629879A3 |
METHOD FOR TREATING DISORDERS IN COGNITIVE FUNCTION |
1995 |
- Besli Charl'Z Merritt Ml.
|
RU2176914C2 |
DERIVATIVES OF TRIAZOLO-(PYRROLO-, THIENO- OR FURANO)-AZEPINE ELICITING ANTIALLERGIC ACTIVITY, METHOD OF THEIR SYNTHESIS, INTERMEDIATE COMPOUND FOR THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF ITS PREPARING |
1993 |
- Frans Ehduard Zhansen
- Zhan Fernan Arman Lakranpe
- Izabell' Noehll' Konstans Pilat
|
RU2127737C1 |
METHOD OF PREPARING AMINODERIVATIVES OF 2-METHYL-5-(2-OXYSTYRYL)-1,3,4-THIADIAZOE OR THEIR SALTS |
0 |
- Peter Klaus Time
- Fritts-Frider Frikel
- Khelmut Khagen
- Albrekht Franke
- Diter Lenke
- Josef Gris
|
SU816402A3 |
METHOD OF PREPARING IMIDAZO (2,5-A)-(1,4)-DIAZEPIN COMPOUNDS OR THEIR PHARMECETICALLY ADOPTED SALTS |
0 |
- Rodnij Aen Frajer
- Armin Valzer
|
SU814278A3 |
METHOD OF PRODUCTION OF (1.2)-ANILINATED 1.4-BENZODIAZOPINES OR THEIR OPTICAL ISOMERS OR ACID-ADDITIVE SALTS |
0 |
- Khans Lipmann
- Mikael Ruland
- Kherbert Myush
- Verner Benzon
- Khennig Khajnemann
- Khorst Tsojgner
|
SU1331431A3 |
METHOD OF SYNTHESIS OF 1-[[[5-(4-CHLOROPHENYL)-2-FURANYL]METHYLENE]AMINO]- 3-[4-(4-METHYL-1-PIPERAZINYL)BUTYL]-2,4-IMIDAZOLIDINEDIONE DIHYDROCHLORIDE |
1999 |
- Mehtson Patritsija Ehnn
- Godlevski Majkl Selden
- Korroz Daniehl
- Guggisberg Iv
|
RU2194706C2 |
DIAZEPINONE DERIVATIVES, METHODS OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION |
1992 |
- Vol'Fgang Ehberlajn[De]
- Gerkhard Mim[De]
- Vol'Fkhard Ehngel'[De]
- Klaus Rudol'F[De]
- Khengi Duds[Nl]
- Kharal'D Tsigler[At]
- Mikhaehl' Ehnttserot[De]
|
RU2081870C1 |