SYNTHESIS OF 2-METHYL-4-(4-METHYL-1-PIPERAZINYL)-10H-THYENO[2, 3-b] [1,5]BENZODIAZEPINE AND ITS SALTS Russian patent published in 2011 - IPC C07D495/04 

Abstract RU 2435775 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to organic chemistry, more specifically to a method of olanzapine purification which involves mixing olanzapine with an organic acid in an organic solvent or a mixture of organic solvents to prepare acid-additive olanzapine salt, precipitation and isolation of acid-additive olanzapine salt and transforming acid-additive olanzapine salt in olanzapine; the organic acid is carboxylic acid which is selected from the group including oxalic, fumaric and benzoic acid.

EFFECT: invention refers to methods for producing pure olanzapine, intermediate products and acid-additive olanzapine salts which in turn can find application for producing pure olanzapine used for preparing a drug for treating mental disorders and conditions.

38 cl, 1 tbl, 25 ex

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RU 2 435 775 C2

Authors

Mesar Tomaz

Tsopar Anton

Shturm Khubert

Ludesher Iogannes

Dates

2011-12-10Published

2005-03-17Filed