DERIVATIVES OF TRIAZOLO-(PYRROLO-, THIENO- OR FURANO)-AZEPINE ELICITING ANTIALLERGIC ACTIVITY, METHOD OF THEIR SYNTHESIS, INTERMEDIATE COMPOUND FOR THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF ITS PREPARING Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of triazolo-(pyrrolo-, thieno- or furano-)-azepine of the general formula (I) , their pharmaceutically acceptable additive salts and stereochemical isomers where each of dotted line means independently optional bond; E-G is a bivalent radical of the formula -X-C(R¹)= CH- or -CH=C(R²) where X means O, S or NR³; R¹ and R² - hydrogen atom; -B=D= is a bivalent radical of the formula C(R)⁴ or -N=C(R⁵) where R⁴ and R⁵ - hydrogen atom; L is H, C_1-6-alkyl possibly substituted with hydroxyl, alkoxyl, hydroxycarbonyl, aryl or arylhydroxy-group, C_3-6-alkenyl substituted with aryl and each aryl means phenyl-group possibly substituted with halogen or alkoxy- -group, or L is a radical of the formula -Alk-Het³ where Alk is C_1-4-alkanediyl; Het³ is a radical of the formula (a) where A-Z means (CH₂)₄ or -CH=CH-CH=CH-. Compounds of the formula (I) show antiallergic activity. EFFECT: improved method of synthesis, enhanced pharmacological activity. 17 cl, 18 ex