12-ARYL PROSTAGLANDIN ANALOGUES Russian patent published in 2012 - IPC C07C405/00 A61K31/5575 A61P27/06 

FIELD: medicine, pharmaceutics.

SUBSTANCE: claimed invention relates to compounds of formula

, where Y represents carbonic acid, or its amide or ether, containing from 0 to 12 carbon atoms; A represents -(CH₂)₆-, cys-CH₂CH=CH-(CH₂)₃- or -CH₂C=C-(CH₂)₃- where 1 or 2 carbon atoms can be substituted by O; or A represents -(CH₂)_m-Ar-(CH₂)₀-, where Ar represents unsubstituted phenyl, thienyl or thiazolyl, sum of m and o constitutes from 1 to 4, and where one CH₂ can be substituted by O; X represents CHCl; R represents group hydrocarbyl or hydroxy hydrocarbyl, containing from 1 to 12 carbon atoms; D represents hydrogen; and n represents integer number from 3 to 4. Also described are ophthalmologically acceptable liquids based on such compounds.

EFFECT: compounds are selective agonists of prostaglandin EP₂ and can be useful for treatment of glaucoma or for reduction of intraocular pressure.

27 cl, 2 ex, 4 tbl, 27 dwg