FIELD: medicine, pharmaceutics.
SUBSTANCE: described are novel compounds of general formula I:
(where values R1-R5, X and Z are defined in invention description), pharmaceutical composition, which contains them, and application of claimed compounds as MGLUR5 modulators for inhibition of transient relaxations of lower esophageal sphincter or for treatment or prevention of gastroesophageal reflux disease.
EFFECT: obtaining compounds for treatment or prevention of gastroesophageal reflux disease.
14 cl, 87 ex
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