TETRAZOLE COMPOUNDS AND USE THEREOF AS ANTAGONISTS OF METABOTROPIC GLUTAMATE RECEPTOR Russian patent published in 2009 - IPC C07D401/14 C07D403/12 C07D401/12 C07D403/06 C07D487/04 A61K31/41 A61K31/4439 A61K31/496 A61P25/00 

Abstract RU 2372347 C2

FIELD: chemistry.

SUBSTANCE: present invention relates to a tetrazole compound with general formula I , where X3 and X4 are independently N and C, where one of X3 and X4 is certainly C; P is phenyl; m equals 1 or 2, where if m equals 1, R1 is bonded to P through a carbon atom on ring P in the meta-position of ring P relative the point at which P is bonded to X3, and if m equals 2, R1 is bonded to P through a carbon atom on ring P in positions 2 and 5 of ring P; R1 is halogen, C1-6alkyl, OC1-6alkyl or cyano group; X1 is C2-3alkyl, C2-3alkenyl, NR3, O, S, CR3R4, SO, SO2; X2 is a bond, CR3R4, O, S, NR3, SO, SO2; R3 and R4 are independently chosen from a group which consists of hydrogen, hydroxy, C1-6alkyl; Q is triazolyl, piperazinyl, or triazole or imidazole ring, condensed with a 6- or 7-member heterocyclic ring with one or two N atoms as heteroatoms; R is C1-6alkyl, C3-6cycloalkyl, pyridinyl, which can be substituted with a nitro, cyano, halogen or OC1-4alkyl group; phenyl, which can be substituted with a halogen, C1-4alkyl, OC1-4alkyl group; (CO)OC1-4alkyl; pyrimidinyl, which can be substituted with a OC1-4alkyl group; p equals 0, 1 or 2, or pharmaceutically acceptable salt or hydrate thereof.

EFFECT: invention also relates to method of inhibiting activity of mGluR5 receptors.

11 cl, 44 ex

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RU 2 372 347 C2

Authors

Jokhansson Martin

Minidis Aleksandr

Staaf Karin

Vensbo David

Makleod Donal'D

Ehdvards Luiza

Ajzek Metvin

O`Brajen Ehnn

Slassi Abdel'Malik

Ksin Tao

Dates

2009-11-10Published

2005-02-17Filed