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IPC

A61K39/39(2006-01-01)

C07H3/06(2006-01-01)

C07H15/24(2006-01-01)

(21) (22)

Application

2010122159/10, 2010-05-31

(24)

Start date

2010-05-31

(22)

Actual filing date

2010-05-31

(45)

Published

2012-01-20

(72)

Inventor

Sanina Nina MikhajlovnaKostetskij Ehduard JakovlevichTsybul'Skij Aleksandr Vasil'EvichKrasil'Nikova Aleksandra OlegovnaNovikova Ol'Ga DmitrievnaPortnjagina Ol'Ga Jur'EvnaShnyrov Valerij LeonidovichBogdanov Mikhail Vasil'Evich

(73)

Holder

Federal'Noe Gosudarstvennoe Avtonomnoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Federal'Nyj Universitet"

METHOD OF REGULATING ANTIGEN IMMUNOGENICITY Russian patent published in 2012 - IPC A61K39/39 C07H3/06 C07H15/24

Abstract RU 2440141 C1

FIELD: medicine.

SUBSTANCE: method of antigen immunogenicity regulation includes incorporation of antigen into structure of immunostimulating complex (TI-complex) - antigen carrier. As protein antigen used is porin from Yersinia pseudotuberculosis, its carrier being immunostimulating complex in form of ultramicroscopic tubules (TI-complex), which consists of mixture of triterpene glycoside cucumarioside A₂-2 (CD), cholesterol and polar lipid of monogalactosyldiacylglyceride (MGDG) from marine macrophytes with weight ratio CD:cholesterol:MGMD 6:2:4. Variation of lipid antigen surrounding is achieved due to application of MGDG with various fatty acid composition, separated from various species of marine macrophytes.

EFFECT: method makes it possible to carry out targeted regulation of immune response to antigen not only due to change of quantitative but also qualitative composition of the complex, and obtain new optimal means of specific prevention against causative agents of pseudotuberculosis and other infectious diseases.

3 cl, 6 dwg, 2 tbl, 6 ex

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RU 2 440 141 C1

Authors

Sanina Nina Mikhajlovna

Kostetskij Ehduard Jakovlevich

Tsybul'Skij Aleksandr Vasil'Evich

Krasil'Nikova Aleksandra Olegovna

Novikova Ol'Ga Dmitrievna

Portnjagina Ol'Ga Jur'Evna

Shnyrov Valerij Leonidovich

Bogdanov Mikhail Vasil'Evich

Dates

2012-01-20—Published

2010-05-31—Filed