FIELD: medicine.
SUBSTANCE: pharmaceutical oral compositions having anti-obesity activity and peripheral action include the premix with low adhesion manufactured from pure orlistat as an active ingredient and excipients that give stability to the premix. Pharmaceutical compositions for the invention preferably include microcrystalline cellulose, lactose monohydrate, sodium laurilsulfate, anhydrous colloidal silicon dioxide, carboxymethyl starch and sodium stearilfumarate. The method for production of said compositions is also proposed. Orlistat content in the premix is less than 20% from total mass of composition, preferably from 12% to 17%. Pharmaceutical compositions may be manufactured from the premix both in form of tablets with marks and in form of powder for suspension making. The invention provides the possibility to take different orlistat doses depending on the patient needs.
EFFECT: simple and economic method of orlistat composition manufacturing without losses caused by degradation of active compound - orlistat.
19 cl, 9 ex
