THE PHARMACEUTICAL COMPOSITIONS CONTAINING pH - DEPENDENT MEDICAL PRODUCT, THE pH MODIFIER AND THE SLOWING DOWN AGENT Russian patent published in 2012 - IPC A61K31/00 A61K31/506 A61K47/12 A61K47/38 A61K9/16 A61K9/22 A61K9/28 

FIELD: pharmaceutical industry.

SUBSTANCE: pharmaceutical composition represents a minitablet or pellet, covered with an isolating layer and enteric cover. The minitablet or pellet contains a pH-dependent medical product, preferably, dipiridamol, and the рН modifier, chosen of the group consisting the following components: lemon acid, fumaric acid, amber acid, adipic acid and maleic acid. The isolating layer includes polymer, softener and the agent reducing stickiness, and separates a minitablet or pellet from enteric covering. The рН modifier ratio to the pH-dependent medical product is from 0,2:1 to 2:1. The full liberation of the medical product from the pharmaceutical composition occurs simultaneously with the рН modifier liberation during the time periodfrom 1 till 4 hours.

EFFECT: invented pharmaceutical compositions are characterized by decrease in variability and bioavailability increase in the body of one patient or more patients.

7cl, 3 dwg, 7 ex